Don't take any benzodiazepines or medicines that could cause drowsiness or sleepiness during treatment method with Promethazine with Codeine Oral Resolution. Request your healthcare provider for a listing of these medicines if You're not absolutely sure.
Unresponsive Cough The dosage of Promethazine with Codeine Oral Alternative really should not be greater if cough fails to respond; an unresponsive cough need to be reevaluated in five days or faster for achievable underlying pathology, such as overseas physique or lower respiratory tract sickness [see Dosage and Administration (2.3)].
system to possess children. Promethazine with Codeine Oral Solution may perhaps impact the ability to have a kid in ladies and males (fertility complications). It's not necessarily acknowledged if these fertility difficulties will probably be reversible, even after you stop getting Promethazine with Codeine Oral Remedy.
Codeine is amongst the Obviously taking place phenanthrene alkaloids of opium derived from the opium poppy; it is assessed pharmacologically being a narcotic analgesic.
Promethazine is contraindicated in comatose states, As well as in persons acknowledged being hypersensitive or to obtain experienced an idiosyncratic response to promethazine or to other phenothiazines.
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4)]. Observational scientific tests have demonstrated that concomitant utilization of opioid analgesics and benzodiazepines enhances the risk of drug-associated mortality in comparison to utilization of opioids by yourself. As a consequence of similar pharmacologic Homes, it can be reasonable to anticipate related danger with concomitant utilization of opioid cough prescription drugs and benzodiazepines, other CNS depressants, or alcohol.
Stimulation can be apparent, particularly in youngsters and geriatric individuals. Convulsions may well not often arise. A paradoxical response has actually been claimed in small children acquiring solitary doses of seventy five mg to 125 mg orally, characterised by hyperexcitability and nightmares.
in rare circumstances when DXM is taken with decongestants, deficiency of oxygen into the brain, producing lasting check here brain injury
Usually do not give wockhardt w/ codeine cough syrup Oral Solution to youngsters younger than 18 many years of any age after tonsillectomy or adenoidectomy surgical procedures.
Promethazine Carcinogenicity experiments had been performed with promethazine hydrochloride. Two-yr research in F344/N rats and B6C3F1 mice were conducted to evaluate the carcinogenic opportunity of promethazine hydrochloride. No proof of tumorigenicity was observed in male and female rats at promethazine hydrochloride oral doses up to 33 mg/kg/working day for 5 click here days/week (approximately such as ten instances the MRHD on a mg/m2 basis).
Notify your health practitioner straight away if you read more have any type of side effects then promptly consult your health practitioner. This medication may well induce serious problems here in uncommon situations for example neuroleptic malignant syndrome.
Promethazine is metabolized because of the liver to several different inactive metabolites which include sulfoxides of promethazine, N-demethylpromethazine as well as get more info other glucuronides.
Just before making use of this medication, go through the guidelines labeled to the medication very carefully. For those who have any queries connected with the medication then you can talk to your doctor.